Disease related mutations in PI3Kγ disrupt regulatory C-terminal dynamics and reveals a path to selective inhibitors | bioRxiv
IJMS | Free Full-Text | Synergistic Interactions of Cannabidiol with Chemotherapeutic Drugs in MCF7 Cells: Mode of Interaction and Proteomics Analysis of Mechanisms | HTML
The XPB Subunit of the TFIIH Complex Plays a Critical Role in HIV-1 Transcription, and XPB Inhibition by Spironolactone Prevents HIV-1 Reactivation from Latency | Journal of Virology
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Transcriptome alteration in Phytophthora infestans in response to phenazine-1-carboxylic acid production by Pseudomonas fluorescens strain LBUM223 | SpringerLink
Patient-specific Boolean models of signalling networks guide personalised treatments | eLife
Translesion DNA synthesis mediates acquired resistance to olaparib plus temozolomide in small cell lung cancer | Science Advances
ERAD deficiency promotes mitochondrial dysfunction and transcriptional rewiring in human hepatic cells - Journal of Biological Chemistry
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Targeting telomerase reverse transcriptase with the covalent inhibitor NU-1 confers immunogenic radiation sensitization - ScienceDirect
HSP90 inhibition downregulates DNA replication and repair genes via E2F1 repression - Journal of Biological Chemistry
Mitochondrial damage-associated molecular patterns trigger arginase-dependent lymphocyte immunoregulation - ScienceDirect
A Chemical Probe for Tudor Domain Protein Spindlin1 to Investigate Chromatin Function | Journal of Medicinal Chemistry
PDE inhibition in distinct cell types to reclaim the balance of synaptic plasticity
Complex FFA1 receptor (in)dependent modulation of calcium signaling by free fatty acids - ScienceDirect
FURIN Inhibition Reduces Vascular Remodeling and Atherosclerotic Lesion Progression in Mice | Arteriosclerosis, Thrombosis, and Vascular Biology
The XPB Subunit of the TFIIH Complex Plays a Critical Role in HIV-1 Transcription, and XPB Inhibition by Spironolactone Prevents HIV-1 Reactivation from Latency | Journal of Virology
IJMS | Free Full-Text | A Transcriptomic Approach to Elucidate the Mechanisms of Gefitinib-Induced Toxicity in Healthy Human Intestinal Organoids | HTML
